IMPORTANT SAFETY INFORMATION

This Patient Information should be read before you start taking sumatriptan and each time you get a refill. There may be new information. This information does not take the place of talking with your healthcare provider about your medical condition or treatment.

What is the most important information I should know about sumatriptan injection?

Sumatriptan can cause serious side effects, including:

Heart attack and other heart problems. Heart problems may lead to death.

Stop taking sumatriptan and get emergency medical help right away if you have any of the following symptoms of a heart attack:

• discomfort in the center of your chest that lasts for more than a few minutes, or that goes away and comes back

• severe tightness, pain, pressure, or heaviness in your chest, throat, neck, or jaw

• pain or discomfort in your arms, back, neck, jaw, or stomach

• shortness of breath with or without chest discomfort

• breaking out in a cold sweat

• nausea or vomiting

• feeling lightheaded

Sumatriptan is not for people with risk factors for heart disease unless a heart exam is done and shows no problem. You have a higher risk for heart disease if you:

• have high blood pressure

• have high cholesterol levels

• smoke

• are overweight

• have diabetes

• have a family history of heart disease

What is sumatriptan?

Sumatriptan is a prescription medicine used to treat acute migraine headaches with or without aura and acute cluster headaches in adults who have been diagnosedwith migraine or cluster headaches.

Sumatriptan is not used to treat other types of headaches such as hemiplegic (that make you unable to move on one side of your body) or basilar (rare form of migraine with aura) migraines.

Sumatriptan is not used to prevent or decrease the number of migraine or cluster headaches you have.

It is not known if sumatriptan is safe and effective in children under 18 years of age.

Who should not take sumatriptan injection?

Do not take sumatriptan injection if you have:

• heart problems or a history of heart problems

• narrowing of blood vessels to your legs, arms, stomach, or kidney (peripheral vascular disease)

• uncontrolled high blood pressure

• hemiplegic migraines or basilar migraines. If you are not sure if you have these types of migraines, ask your healthcare provider.

• had a stroke, transient ischemic attacks (TIAs), or problems with your blood circulation

• taken any of the following medicines in the last 24 hours:

- almotriptan (AXERT®)

- eletriptan (RELPAX®)

- frovatriptan (FROVA®)

- naratriptan (AMERGE®)

- rizatriptan (MAXALT®, MAXALT-MLT®)

- sumatriptan and naproxen (TREXIMET®)

- ergotamines (CAFERGOT®, ERGOMAR®, MIGERGOT®)

- dihydroergotamine (D.H.E. 45®, MIGRANAL®)

Ask your healthcare provider if you are not sure if your medicine is listed above.

• an allergy to sumatriptan or any of the ingredients in sumatriptan injection. See the end of this leaflet for a complete list of ingredients in sumatriptan injection.